Brain-implantable devices such as those used in deep brain stimulation (DBS) have a promising future in end-stage Parkinson’s disease. However, inserting electrodes into the brain can cause astrocytic gliosis, inflammation and cell dystrophy, which is a major source of failure in chronically implantable electrodes. It is known from previous experiments that resveratrol significantly reduced tissue damage caused by DBS, however, because the metabolic half-life of resveratrol is short, an analog with longer biological activity is necessary. Our main hypothesis in this study is to test the effectiveness of CRB, a synthetic derivative of resveratrol, on reducing tissue damage caused by DBS. In this presentation the design and synthesis of CRB will be described, along with the effects of CRB on preventing neuronal damage <i>in vivo</i> inflicted by DBS.<br/>

Synthesis and design of CRB, a resveratrol analog, reduces cell injury caused by surgery mimicking deep brain stimulation

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.