Trends in drug discovery are changing rapidly. During the past decade, terms “Scaffold hopping,” “Escape the Flatland” and “Conformational restriction” have been introduced, and have already found huge practical application. In this context, in recent years medicinal chemists often use bicyclic Fsp3-rich building blocks in drug discovery projects. In this work, we have designed, synthesized and applied novel multifunctional bicyclic cores for drug discovery. Details of the synthesis and application of the obtained compounds will be discussed.

Synthesis of novel bicyclic amines and their application for drug design

2019 Spring National Meeting

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