The development of innovative synthetic strategies for the assembly of natural products enables the systematic evaluation of a molecules’ biological function and can serve to generate novel chemical probes and therapeutic lead molecules.  Given the dire need for novel scaffolds to fight the growing threat of antimicrobial resistance, the ability to access scaffolds with antibacterial activity and achieve deep-seated, pin-point modifications to their structures is critical. Herein, our effots to utilize marine natural products as scaffolds for infectious disease drug discovery will be discused, highlighted by our efforts on the lipoxazolidinones.  <br/>

Molecule-driven discovery for the identification of therapeutic leads

2019 Spring National Meeting

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