Modern drug discovery is hard to imagine without fluorine: ca. 20% of all pharmaceuticals contain this element. To date, however, only a tiny part of the theoretically possible building block structures are synthesized. Many simple combinations of fluorine with carbon and nitrogen atoms are still unknown.<br/>Commercially accessible fluorinated alicyclic amines are mostly limited to pyrrolidines and piperidines. The latter are quite popular in medicinal chemistry. In this work, we synthesized a library of novel aliphatic saturated amines. Details of their design and synthesis will be reported.

Synthesis of novel, pharmaceutically relevant fluorinated amines

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.