The need for productivity and efficiency improvements in the manufacturing of Biopharmaceutical products has resulted in evaluating numerous process intensification strategies both upstream and downstream. Use of various process and cost modeling tools like BioSolve software can shed light in identifying process steps with the most significant impact on overall process economics and facility planning. The information then can be used to guide the process scientists and engineers to invest their time and effort into optimizing the steps that deliver the best overall outcome.<br/>The presentation covers numerous case studies comparing different technologies and processing options evolving in the field of intensification.  The model case studies focus on various upstream scenarios, comparing a normal fed-batch process to N-1 perfusion strategy to concentrated fed-batch approach. The application of the appropriate intensified approach to different product throughput demands is explained considering the impact of process design and technology choices on the overall cost of goods. The retrofitting of an existing facility to produce multiple products is demonstrated by simply moving from a fed-batch to intensified approach.<br/>

Does process intensification add value in light of cost and facility planning

2019 Spring National Meeting

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