The number of people suffering from depression exceeded 300 million, as shown a report of WHO (World Health Organization)[1]. The genesis of depression is associated with an inadequate level of some neurotransmitters, especially serotonin[2]. Currently, many drugs that control serotonin level are known, however, they are not effective enough and cause many side effects[3]. This is the reason to look for new, more effective antidepressants. Among the commercially available drugs, a group of compounds with a strong affinity for serotonin receptors is distinguished. These ligands belong to long-chain arylpiperazines having a 1,2-benzisothiazol-3-yl fragment attached to the piperazine ring. To this group belong Lurasidone[4], Perospirone[5] and Ziprasidone[6]. In the presented studies a new long-chain derivatives of 1-(1,2-benzisothiazol-3-yl) piperazine were synthesized. The obtained compounds were characterized for their affinity for selected receptors: D2, 5-HT1A, 5-HT2A, 5-HT6 and 5-HT7. In addition, a new ecological, microwave assisted method of synthesis for the described compounds was developed. The obtained compounds were characterized by high affinity for mentioned receptors, which makes it possible to use them as potential drugs.

New long-chain derivatives of 1-(1,2-benzisothiazol-3-yl)piperazine with high affinity for selected serotonin receptors

2019 Spring National Meeting

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