There has been a great interest lately to identify natural products from maple syrup, produced mainly in the Province of Quebec, using the sap of <i>Acer saccharum L.</i>. Studies led to the identification of quebecol, a novel polyphenol found only in maple syrup. Unfortunately, the low abundance of quebecol in the syrup limited its bioactivity studies. To overcome this limitation, we developed a synthetic strategy to access not only quebecol in larger quantities, but also several of its analogs. We will report our results on the total synthesis of quebecol and its analogues, describing our recent efforts to improve key steps. Also, we will describe the anti-inflammatory properties of all analogues prepared.

Synthesis and characterization of quebecol and its analogues

2019 Spring National Meeting

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