Methimazolium based ionic liquids possessing two lipidic tails of varying length, either C16, C18, or C20, have been synthesized for use as gene transfection agents. Methimazole provides a well distributed positive charge located at the head which will bind efficiently to DNA. The sulfur moiety lengthens the hydrophobic domain without increasing the toxicity of the product. The synthesis of these compounds was achieved via SN2 reactions. NMR spectroscopy, DSC, and TGA were conducted for characterization of all. These ionic liquids have proven to be effective gene delivery agents accompanied with low toxicity.

Methimazolium-based ionic liquids as potential gene delivery vectors

2019 Spring National Meeting

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