Nanofiltration is a key component of pathogen safety in bioprocessing. However, fundamental structure-performance correlations in nanofilters to date are limited, largely due to the non-uniform structure of existing filter membrane materials. Here, we employ self-assembling of block copolymers to form isoporous membranes with high pore densities and narrow pore size distributions. This technology is also scalable to industrial membrane manufacturing processes. Our nanofilters were evaluated in viral clearance applications for both downstream (DS) and upstream (US) monoclonoal antibody (mAb) manufacturing, using a panel of commercial mAbs and US cell culture feed streams, respectively. In this poster, structure-property relationships on the nanofilters are reviewed with a particular emphasis on viral clearance and capacity performance for bioprocessing.

Self-assembled isoporous nanofilters for high throughput viral clearance applications in bioprocessing

2019 Spring National Meeting

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