The platinum-containing coordination compound cisplatin is one of the most commonly used chemotherapeutic agents for the treatment of cancer. Despite its widespread implementation, it suffers from a number of drawbacks that limit patient survival rates and quality of life. The investigation of alternative metals complexes for the treatment of cancer remains a promising approach to develop new drug candidates. In this context, this presentation will discuss our group’s efforts to probe complexes of rhenium as novel anticancer agents. We will discuss three classes of these compounds that exhibit promising in vitro and in vivo anticancer activity. Studies on their mechanism of action will be described, noting key differences in how these compounds are causing cell death. Overall, this presentation will highlight the promising potential of complexes of rhenium for the treatment of cancer.<br/>

Cancer cell death induced by rhenium anticancer agents

2019 Spring National Meeting

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