L-Arginine (LA) is commonly used as a workout supplement to increase athletic stamina and ability. The low oral bioavailability of LA has led to the synthesis of new molecules such as l-arginine ethyl ester (LAEE). LAEE is argued to have a higher bioavailability than LA because of an increase in hydrophobic properties. The kinetic mechanism of the non-enzymatic hydrolysis of LAEE, with a specific emphasis on the physiological pH conditions found in the body (2.5, 8.1, and 7.4) is the subject of this study. Apparent rate constants were measured by performing rate experiments under pseudo-first order reaction conditions using a phosphate buffer. From these data, a rate law for the hydrolysis of LAEE is proposed.

Proposed mechanism and rate law for the non-enzymatic hydrolysis of l-arginine ethyl ester

2019 Spring National Meeting

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