Nonsteroidal anti-inflammatory drugs (NSAIDs) are broadly used over the counter drugs. Their leakage into the environment demands a fast and sensitive method for their detection in aqueous solution. When these drug molecules were combined with fluorescent functional monomers containing thiourea binding groups in surfactant micelles, the hydrophobic environment of the micelle helped stabilize the hydrogen-bonding interactions in water. Double-cross-linking of the mixed micelle on both the surface and in the core created binding pockets inside the micelle complementary to the initial template molecules. The fluorophore in the binding site showed large changes in emission when the matched drug molecule (i.e., the template) were present in solution but showed little change toward analogous drugs or other small molecule carboxylic acids.

Molecularly Imprinted Nanoparticles (MINP) as fluorescent sensors for Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

2019 Spring National Meeting

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