The rise of synthetic opioids has highlighted the need for new long acting opioid antidotes. Currently available antidotes to reverse an opioid overdose (e.g. naloxone) have short pharmacokinetic half-lives due to rapid metabolism in the liver. Due to the relatively long circulatory times of synthetic opioids such as fentanyl a phenomenon known as renarcotization may occur. The short half-life of these antidotes requires multiple repeat doses to reverse a synthetic opioid overdose. We present a novel polymer based drug delivery system that incorporates a high loading of naloxone into a polymer nanoparticle with zero order sustained release to act as a long acting opioid reversal agent.

Next-generation opioid antidotes: Covalent nanoparticles for the delivery of Mu opioid antagonists

2019 Spring National Meeting

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