Our long-term research goal is developing synthetic catalysts or reagents that surrogate enzymes, and using the synthetic catalysis in our body as a new paradigm of medicine (catalysis medicine). This research direction will in turn contribute to green synthesis of functional molecules, including drugs, in test tubes or larger-scale artificial reaction vessels. To do so requires powerful catalysts or reagents, which can functionalize stable, multifunctional molecules ranging from small molecules to biomacromolecules, under mild conditions and protecting group-free settings with synthetically-valuable selectivity (e.g. chemo-, target-, site-, and residue-selectivity).<br/>Protein bioconjugation is a fascinating and very important target for methodology development along such direction. We are especially interested in protein modifications through modulating the redox states. We developed a tryptophan-selective bioconjuation of proteins using an organo-radical, keto-ABNO. I will discuss and update the strength and application of the method in my presentation.

Transition-metal-free, tryptophan-selective bioconjugation of proteins

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.