A stackable, pre-packed chromatography cassette with a resin bed support structure is a novel platform concept in chromatography, combining the separation capabilities of conventional chromatography resins with the benefits of a modular cassette format. This device enables flexible scaling to meet capacity requirements and provides high convenience. Due to the supportive lattice inside the cassette, this chromatography format allows very high flow rates and scaling-up of short bed heights.<br/>The science behind a number of application data with this cassette format will be presented, including 1<sup>st</sup> principle analysis of the chromatographic performance of single and stacked cassettes, a continuous antibody capture step and a hyper-productive rapid cycling antibody capture process with a new Protein A resin prototype. Furthermore, results of CFD modeling will be shown to demonstrate the fluid distribution in the cassette, in combination with scale-up process performance data from industrial testing.

Enabling high productivity processes with a stackable chromatography cassette: Synergy of device, resin and process design

2019 Spring National Meeting

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