The Division of Preclinical Innovation at the National Center for Advancing Translational Sciences, NIH, often engages in phenotypic screening campaigns followed by medicinal chemistry to discover small molecules that reverse disease phenotypes in cell-based assays. This often catalyzes follow up efforts to deconvolute the small molecule’s biological target leading to its mechanism of action. Case studies from collaborative projects will be presented with an introduction to the screening paradigm and the approaches that led to the discovery of possible valid targets for the active small molecule.

Small molecules from phenotypic screens: Looking for “a” target?

2019 Spring National Meeting

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