Silicone microspheres synthesized using ultrasonic spray pyrolysis have been studied for their potential biomedical applications in controlled drug release and delivery. In this study, four silicone based polymers were synthesized from a recently published method and were characterized using SEM and swelling coefficients.  The drug loading in various loading solvents and the release kinetics were measured using ibuprofen as a sample pharmaceutical. The different polymers and the different swelling solvents produced different loading percentages.  The rate of release was also affected by the polymer used.  These studies will lead to a better understanding of the characteristics of the silicone microspheres so that they may be tuned for the application of interest.

Silicone microspheres: Synthesis, characterization, and application

2019 Spring National Meeting

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