The conversion of unactivated Csp3–H bonds to new functional groups represents a major challenge in the chemical synthesis of organic molecules. An attractive approach for achieving this difficult transformation involves metal-catalyzed Csp3–H bond functionalization. Over recent decades, platinum has become recognized as an effective catalyst for the oxidation of unactivated Csp3-H bonds, highlighted in Alexander Shilov’s conversion of methane to methanol. Herein we report recent advancements in the selective functionalization of the Csp3–H bonds in a variety of organic substrates.

Advances in platinum-catalyzed Csp3-H oxidation reactions

2019 Spring National Meeting

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