Heteroaryl compounds are valuable building blocks in medicinal chemistry and chemical industry. A palladium-catalyzed direct α-C(sp3) heteroarylation of ketones under microwave irradiation is developed and reported in this study. Under optimized conditions, over two dozens heteroarylated ketones were prepared, demonstrating the broad substrate scope of this reaction. Density Functional Theory (DFT) was employed to study the possible intermediates and mechanistic pathway for the Palladium-catalyzed Direct α-C(sp3) Heteroarylation of Ketones. This study provided insightful information for catalytic system design to general heteroaryl compounds.

Palladium-catalyzed direct α-C(sp3) heteroarylation of ketones under microwave irradiation

2019 Spring National Meeting

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