Tandem mass spectrometry (MS/MS) is a powerful analytical technique that can be utilized for trace quantitation when coupled with a separation technique such as liquid chromatography (LC). Advanced LC/MS/MS instrumentation has recently been used by Chemours Fluoroproducts Analytical to provide time-sensitive analytical solutions related to environmental concerns surrounding wastewater regulation. Authentic reference standards were synthesized to enable accurate quantitation of per- and polyfluoroalkyl ether carboxylic acids (PFECAs) and sulfonic acids (PFESAs). We will also illustrate the difficulties in quantitation in the absence of authentic standards. An analytical method has been developed to mitigate background contamination while using selective fragmentation to yield highly specific quantitation of fluorinated compounds in the ng/L range.

Quantitation of per- and polyfluoroalkyl ether compounds at trace levels by LC/MS/MS

2019 Spring National Meeting

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