Classical methods for achieving nucleophilic substitutions of alkyl electrophiles (SN1 and SN2) have limited scope and are not generally amenable to enantioselective variants that employ readily available racemic electrophiles. In this presentation, we will describe how the combination of radical chemistry and transition-metal catalysis has opened the door to addressing the challenges of reactivity and of enantioselectivity in nucleophilic substitution reactions of secondary and tertiary alkyl electrophiles.

Nucleophilic substitution reactions: A radical alternative to SN1 and SN2 reactions

2019 Spring National Meeting

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