Downstream process development activities such as tangential flow filtration (TFF) are typically conducted over several hours and often require data collection to assess process performance. The use of automated systems provides a number of advantages such as remote control, continuous data acquisition, and safety features. Unfortunately, the procurement of an automated TFF system can be expensive, and most available systems leave little room for customization. This work demonstrates an inexpensive and flexible solution that operates wirelessly and incorporates existing equipment such as pumps, sensors, and lab computers. A MATLAB application was designed with a straightforward graphical user interface exhibiting real-time running graphs of sensor data, pump and valve controls, and many user-defined settings and safety functions. Subsequently, the application was compiled and distributed to lab computers allowing stand-alone execution and routine data acquisition during TFF experiments. Continuous data from several hours of operation is valuable for process characterization and troubleshooting. Furthermore, the wireless remote control capability facilitates TFF experiments contained in controlled temperature units, biosafety cabinets or other enclosures. The application’s simple design also enables rapid adaptation to different experimental set-ups and even other unit operations. A modified version for large scale chromatography was employed to produce detailed UV chromatograms and collect pulse test conductivity data. Other adaptations of this application can be envisioned for many activities (e.g. normal flow filtration). The built-in safety features and remote operation are especially desirable for work involving potentially harmful biological agents and toxic chemicals. In conclusion, this simple and inexpensive approach has proven to be a versatile solution to data acquisition and remote control needs in downstream process development labs.

Design and implementation of a simple wireless data acquisition and remote control system for downstream process development activities

2019 Spring National Meeting

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