Porphyrins represent one of the most privileged scaffolds found within nature. These and related tetrapyrrolic macrocycles play key roles in many of the biochemical pathways essential for life. Not surprisingly, tetrapyrroles are the focal point of innumerable research programs across the chemical and medical communities. Significant efforts have been made to elaborate the porphyrin periphery,as well as to modify the porphyrin core. In the context of the latter paradigm, an emphasis has been placed on so-called expanded porphyrins. These analogues are typically characterized by a more extensive p-system than present in naturally occurring tetrapyrroles and often offer larger internal lacunae for metal complexation. The larger cavity size of expanded porphyrinoids has found utility in probing the coordination chemistry of the actinyl ions under aqueous and non-aqueous conditions. A summary of my work in this arena, along with an overview of published and ongoing synthetic efforts, will be reviewed in this presentation.

Hybrid and expanded porphyrins: coordination chemistry of the actinide elements

2019 Spring National Meeting

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