<br/><br/>Organic molecules containing one or more fluorine atoms are becoming more important as pharmaceuticals, agrochemicals and materials. The addition of a fluorine atom can dramatically change the pharmacology of a compound by increasing the lipophilicity and the stability of the molecule. Traditionally, less efficient methods using toxic materials and high temperatures were used to fluorinate molecules, but due to the harsh conditions new methods are being developed. The use of electrochemical methods as the means to fluorinate molecules allow for energy and cost efficiency, as well as being a relatively simple technique. This project is using prior knowledge of formation of C-F bonds in attempt to add a fluorine atom to organic molecules by selectively activating the functional groups using electrochemistry as the energy source. While doing this research, we have observed that there is a radical reaction taking place. Further experiments are being conducted to use electrochemistry to reach the goal of adding the fluorine to the these positions with knowledge that we are successful in running the radical reaction.

Fluorination of molecules using electrochemical methods

2019 Spring National Meeting

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