EMD Serono has a centralized data warehouse for all research data. The datastore captures about two million registered entities, hundreds of millions of biological endpoints as well as half a million documents. To better share data among the internal R&D community, a web-based platform is developed to provide an integrated solution for data retrieval, mining, and analysis.<br/>ARENA360 provides easy browsing functionality for each compound, the data are presented in specific sections: basic chemical structure and related data; compound batches and inventory; and biological assay data grouped by categories – in vitro, in vivo, ADME etc. In addition, by using Chemaxon technology, ARENA360 also provides structure searching functions, as well as advanced data mining options.<br/>In addition to internal data, reference compounds are annotated using Drugbank and Cortellis databases, so data from external databases are also available along with the internal ones. Furthermore, several design tools are integrated, such as nearest neighbor searching and internally developed chemistry design applications.<br/>Compounds are also annotated by their target profiles based on biological assay results, therefore allowing users to drill into biology via the linked target database. Within this target database, users can find target profiles, disease indications, and even competitive intelligence information.<br/>ARENA360 is not limited to NCEs, but also has NBE capabilities. Small molecule and protein drug candidates can be searched and browsed side by side in one web interface. The platform is built based on many emerging technologies for big data and provides an integrated view for the internal and external data for the drug candidates; it is used daily by over a thousand scientists.

ARENA360: An integrated informatics solution for drug discovery

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.