α-Hydroxynitriles were observed and identified as the sole intermediate in the reactions for α-aminonitriles between ketones and sodium cyanide when ammonia and ammonium chloride are present. a- Aminonitriles and a-hydroxynitriles from 3-pentanone,2-heptanone, 4-heptanone, 2-octanone and methyl phenyl ketone were analyzed by NMR, IR and elemental analysis. Valuable kinetic data were collected. It is found that with time the relative concentration of α-hydroxylnitrile was accumulated then decreased with the increase of the relative concentration on α-aminonitrle.

New evidence for the mechanism of Strecker synthesis with ketones as substrates

2019 Spring National Meeting

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