Molecular imaging, such as positron emission tomography (PET), has been widely used in medical research and drug discovery. We have developed new imaging tools and applied them in clinical research and drug discovery. In this presentation, I will discuss the development and application of molecular neuroimaging techniques for brain research. In the past few years, we have developed the first generation of epigenetic PET probes for HDACs and bromodomains. The first probe for class I HDAC imaging has successfully advanced to human imaging studies and shows promising results so far. With these tools, we know the epigenetic changes in patients for the first time, and we also developed a series of new epigenetic inhibitor. Our work is a unique example on the multidisciplinary research, including molecular imaging, medicinal chemistry, clinical research and drug discovery.

Application of PET neuroimaging probes targeting epigenetics

2019 Spring National Meeting

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