The target compound has three major parts, the naphthalimide core with tail, a linker, and the target drug. The naphthalimide core is a photoactive molecule. When exposed to light detaches from the linker-drug portion of the compound. The freed end of the linker then binds with tissue in the body, keeping the drug in the localized region of the body. A hydrolysis reaction then occurs breaking the bond between the linker and the drug. In previous work, a convergent synthesis was established for the synthesis of the target compound. Our research focused on the two synthesizes: the drug derivatives and the drug derivative-naphthalimide compounds.

Synthesis and characterization of drug derivatives and drug derivative-naphthalimide compounds for localized drug delivery

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.