The Sydlik group is developing functional graphenic materials (FGMs) that inherently induce osteogenesis in vitro and in vivo. Specifically, our modified Arbuzov reaction installs polyphosphate on the GO backbone with control over a variety of bioinstructive counter ions (Ca2+, K+, Li+, Mg2+, or Na+). Ca2+, Li+, Mg2+, and PO4-. These ions are known to be inducerons, or small ions that encourage the osteogeneic differentiation of stem cells. Further, we have shown that CaPG induces osteogenesis in vivo in a mouse model. Additionally, we are refining the Claisen reaction to produce Claisen graphene (CG) that attachesstable, cell instructive moieties at the surface. We are also developing the Mitsunobu reaction to occur with GO in very mild conditions to attach sensitive small molecules and growth factors known to promote osteogenesis to the graphenic backbone. Attachment occurs via hydrolytically labile covalent bonds that enable the covalent controlled release from Mitsunobu graphene (MG). The Sydlik group collaborates with Dimension Inx, to produce free standing, porous scaffolds with 90% FGM content, using poly(lactide-co-glycolide) as a binder. These 3D printed FGM scaffolds use the power of chemistry to direct the biological healing response.

3D printing stem cell instructive Functional Graphenic Materials (FGM) for bone regeneration scaffolds

2019 Spring National Meeting

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