Graded surfaces and materials can mimic the graded variations in terms of the extracellular matrix and niche of native tissues. Particularly, they can provide bio-functional substrates and scaffolds to study the fundamental aspects of embryo development and cell behaviors involving chemotaxis, haptotaxis, and mechanotaxis, as well as restore the structures and functions of defected/diseased tissues. In recent years, both planar gradients in two-dimension (2D) and spatial gradients in three-dimension (3D) have been explored for bio-related applications, especially in regulating cell behaviors and guiding tissue regeneration. In this talk, I will use a number of examples from my own group to illustrate how graded surfaces and materials can be fabricated to suit specific applications, including investigation of cell migration and interfacial tissue engineering.

Graded surfaces and materials for biological and biomedical applications

2019 Spring National Meeting

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