Bacterial resistance to antibiotics is a major public health problem and there is an urgent need to find newantimicrobial materials to circumvent the development of resistant pathogens. The aim of this work is topropose an efficient and versatile method for the elaboration of antimicrobial polymeric materials basedon the simple dispersion of a low amount of high molecular weight (Mn&gt; 20 000 g.mol−1) amphiphilic methacrylic copolymers prepared by nitroxide-mediated polymerization in different common organic matrices. More precisely, we proved for instance that only 0.5 wt% of PBMA-bPDMAEMA diblock copolymers dispersed by extrusion in common polymeric matrices (polystyrene, polymethyl methacrylate, polycarbonate, etc.) conferred antibacterial activity to initially inactive organic materials.This approach which does not require the expensive modification of the surface material and which is not based on the dispersion of small molecules (antibiotics or silver nanoparticles for example that can be released from the material) also offers the advantage of furnishing materials that are active against different types of bacteria (E. coli, B. subtilis) without the loss of activity with time or degradation.

Solid antibacterial polymeric materials elaboration by dispersion of amphiphilic methacrylic SG1-based copolymers

2019 Spring National Meeting

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