Tailorable two-dimensional (2D) nanomaterials possess intrinsic fundamental and technological importance. Herein, we demonstrate a simple and general approach for the fabrication of multicomponent nanosheets derived from collagen-mimetic peptides (CMPs) via seeded growth assembly methods. Utilizing CMPs engineered to have different melting properties, “shell” CMPs and pre-assembled “core” CMP nanosheets are combined <i>in situ</i> and assembled together under controlled annealing conditions. The resultant assemblies exhibit a core-shell assembly architecture, where both the core and shell components can be individually functionalized. Furthermore, we demonstrate that this method allows for systematic control over sheet sizes in all dimensions. These 2D architectures represent novel biocompatible platforms for controlling the spatial arrangement and presentation of chemical functionality at the nano- and mesoscale regime. We anticipate that this strategy will serve as a platform for the construction of designer biomolecular 2D nanoarchitectures.

2D multicomponent core-shell nanosheets fabricated from designed collagen-mimetic peptides

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.