Various natural products and pharmaceutical targets contain the six-membered C,N-heteroatom ring skeleton of quinazoline and quinazolin-4-one. Synthetic methods toward these rings have been continuously developed and reported. Unlike those reactions utilizing numerous toxic chemical reagents, we developed a new route for the green synthesis of quinazoline and quinazolin-4-one derivative by microwave and electrochemical reactions. In this pathway, none of toxic chemical reagents and transition-metal-catalysts are used and their corresponding hazardous chemical waste are avoided, which matches the goal of Green Chemistry. This green pathway has been applied in the total synthesis of pharmaceutical targets. Detail information will be discussed in the meeting.

Synthesis of quinazoline and quinazolin-4-one derivatives in green pathway: Utilizing microwave and electrochemical reactions

2019 Spring National Meeting

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