The interaction between gold nanoparticles (AuNPs) and blood plasma or serum proteins has been well studied by many research groups. Upon mixing AuNPs with a blood plasma or serum samples, a protein corona is formed almost instantly on the AuNP surface. In our previous research, we demonstrated that the size and the composition of this protein corona is dependent on the disease status of the blood donor. Here, we report our most recent finding that links the protein corona composition of the AuNP to the immunity and immune status of murine and bovine models from neonates to adults. The average particle size of the gold nanoparticle-serum mixture, measured by dynamic light scattering, corresponds positively to the immune status and activity of the subject. A well-developed, functional immune system is paramount to combat harmful attack from pathogenic organisms and prevent infectious diseases. Our study established the feasibility of a convenient test not only for monitoring the immune function development from animals and humans, but also for detecting active immune responses during infection.

Gold nanoparticle-blood serum interaction assay reveals humoral immunity development and immune status of animals from neonates to adults

2019 Spring National Meeting

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