Supramolecular catalysis is the self-assembly of catalyst species by using multiple weak inter/intramolecular interactions. Guanosine is found to be good self-assembly material. It has multiple chiral centers and can work as catalyst. Guanosine can easily form one supramolecular by self-assembly. In our research, we link amine with our designed Guanosine derivative. Eight such compounds form final catalyst by self-assembly. The supramolecular works as catalyst to catalyze asymmetric synthesis. Our target molecular has huge space hindrance in the one side. Plus, there is a chiral center in Guanosine derivative part. So the two factors make it be good supramolecular catalyst and give high asymmetric catalytic ability.

Supramolecular catalysis

2019 Spring National Meeting

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