Substituted alkaloids are privileged molecular scaffolds in the field of medicinal chemistry. These molecules are important, as they are abundant among blockbuster drugs and natural products. Thus, there is a continuous demand for the development of more efficient and systematic methods to access such complex molecules. These efforts have found that vinyl-dihydroisoquinolines undergo cycloaddition reactions under photochemical conditions to providethe respective alkaloid scaffolds in high yields and selectivities. This study would provide efficient and continuous access to complex highly functionalized alkaloids from simple scaffolds,which will facilitate the engineering of convergent approaches towards more complex heterocyclic pharmacophores.

Cycloaddition reactions of vinyl-dihydroisoquinolines for the synthesis of complex alkaloids

2019 Spring National Meeting

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