Metal-organic frameworks (MOFs) are a class of crystalline materials with inherent porosity relevant for a wide range of applications. In this study, previously published charged MOFs were synthesized, such as bMOF-1, ZnAdBTC, and ZJU-100. It has been shown that counter-ions can be loaded into charged MOFs, specifically, (1) charged pharmaceuticals to control drug-release, or (2) hydrophobic/hydrophilic ions to tune the MOF stability in aqueous environments. We have loaded the charged MOFs with a combination of pharmaceuticals and counter-ions of varying hydrophobicity. We then studied the drug release mechanism based on MOF degradation. With more hydrophobic character in MOFs, the drug release is slowed, resulting in a slow-release effect. To generate such trends, the concentration of the pharmaceutical present in the solution, starting at time zero until fully released, is determined through magnetic resonance (<sup>1</sup>H NMR) and infrared (IR) spectroscopy measurements. Future assays allow for the MOFs containing the pharmaceuticals and counter-ions to be studied within cells.

Using charged metal-organic frameworks (MOFs) for controlled drug delivery

2019 Spring National Meeting

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