LpxC, an enzyme involved in the first committed step of the biosynthesis of lipid A, has been found to be a crucial drug target. This inhibition is critical for developing novel antibacterial treatments, especially with the growing resistance Gram-negative bacteria is having toward already developed treatments. Through the computational analysis of the crystal structure of LpxC and its active site, novel inhibitors have been designed with the natural substrate of LpxC in mind. A special emphasis has been made on the use of 1,2,3-triazoles as a key component of the proposed analogues, due to the versatility of azides and ease of synthesis through the use of “click chemistry” methods. The computational binding studies, analysis and synthesis of these analogues as well as the different synthetic pathways used to synthesize these compounds will be discussed.

Utilizing triazole-based compounds as potential inhibitors active against gram-negative bacteria

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.