Microwave chemistry is a technique used to synthesize chemical compounds at quicker rates and higher controlled temperatures. Organic chemists have begun to rely on microwave chemistry because this method of synthesis is cleaner, faster and more convenient. In this present study, we have utilized microwave chemistry to carry out traditional organic reactions, such as Nucleophilic Aromatic Substitution reactions (SNAr) and reductions of nitro groups. Recent studies have shown that benzimidazoles compounds, such as Celecoxib, are designed to inhibit P13K pathways and act as anti-cancer agents. We are proposing to utilize microwave chemistry to synthesize these compounds which will be evaluated as anticancer agents against triple negative breast cancer cell lines. We will use a Milestone START and a Discovery CEM Microwave to carry out a 4-step synthetic process. Following the synthesis, the reactions are monitored by Thin Layer Chromatography (TLC), and chemically characterized by Nuclear magnetic resonance (NMR) and Gas Chromatography (GC). All products from step 1 are used to carry out step 2-4 reactions. We have effectively utilized microwave chemistry to carry out multiple reactions in a shorter time span producing better yields.

Synthesis of benzyl sulfamide derivatives using microwave chemistry

2019 Spring National Meeting

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