As a class of unique, functioning polymers, biopolymers often have a set of well-defined structural characters that can be described by contacts. In several situations, expressing information of biopolymer conformations using contacts has several advantages over traditional Cartesian coordinates, from the convenience of data gathering to data reduction and coarse-graining procedures. Different statistical analysis methods of these contact data can provide the consensus of the structural ensemble and the concerted fluctuation around mean. Various types of dynamics, from allosteric motions, protein folding, to chromosome dynamics can be revealed using contact analysis. Specific examples include the allosteric enzyme ribonucleotide reductase, the signaling protein constitutive androstane receptor, and human chromosomes. <br/>

Dynamics of biopolymers studied using statistical analysis of contacts

2019 Spring National Meeting

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