We present the surface functionalization of branched polyethlyeneimine (PEI) coated magnetic nanoparticles for the treatment of prostate cancer. In the present study, Fe3O4 nanoparticles prepared via co-precipitation method with citrate as dispersant was coated with PEI. Thus formed PEI-Fe3O4 nanoparticles were further functionalized with polyethylene glycol (PEG) via free radical reaction between amino groups on the PEI surface and carboxyl groups of PEG-COOH. These nanoparticles were characterized by different chemi-morphological techniques. Well dispersed and easily manipulable sizes were obtained suitable for biomedical purpose. In addition to being smaller in size (10-15 nm), these nanoparticles had good biocompatibility in fairly varying concentration range whereas the PEI-Fe3O4 nanoparticles showed slight toxicity at concentration of 70 μg/mL. Chemotherapeutic drug, doxorubicin and ADAM10 siRNA were co-loaded into the nanoparticles via non-covalent interactions. Drug loading and release were studied and were demonstrated to function synergistically in cytotoxicity analysis against prostate cancer cell line (PC3 cells). In conclusion, PEG functionalized PEI-Fe3O4 nanoparticles could be further utilized for the dual delivery of anti-cancer drugs in drug resistance tumors.

Surface functionalization of polyethyleneneimine coated iron oxide nanoparticles for dual delivery of doxorubicin and ADAM10 siRNA for prostate cancer treatment

2019 Spring National Meeting

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