Protic ruthenium complexes based upon 6,6'-dihydroxybipyridine ligands can be activated by various different mechanisms. They can both photodissociate to expel a ligand and they can also generate singlet oxygen in the cellular environment. We have studied the extent to which these mechanisms contribute to cellular toxicity for different compounds in different environments. We report recent work showing that the uptake of these compounds is pH dependent. In this presentation we report on the synthesis and spectroscopy of new ruthenium anticancer compounds and the ways in which they are activated. We also report on the cellular toxicity and the mode of action of these new compounds.

Singlet oxygen formation vs. photodissociation for protic ruthenium anticancer compounds

2019 Spring National Meeting

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