Nanoparticles are becoming ubiquitous delivery systems in the biomedical sciences and can be layered with different compounds to produce vessels for transportation of biological materials. In particular, gold nanoparticles have successfully been utilized for the delivery of biological materials   into cells. However, gold nanoparticles are synthesized from expensive precursors. Herein, we demonstrate that zinc oxide nanoparticles are more affordable alternatives for the delivery process.  Zinc oxide nanoparticle conjugates were synthesized, modified and utilized for the delivery of proteins and ribonucleic acids. The zinc oxide nanoparticle conjugates were characterized with Dynamic Light Scattering Spectroscopy (particle sizing), Scanning Electron Microscopy (particle size and morphology), Electrophoretic Mobility (surface charge) and UV-Vis Spectrophotometry (optical properties). Preliminary results indicate that the biological activity of the proteins and ribonucleic acids was maintained and, in some cases, even better compared to other nanoconjugates.

Synthesis, modification, and integrity of zinc oxide nanoparticles for RNA delivery

2019 Spring National Meeting

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