Gelatins are mixtures of water soluble proteins obtained by degradation and partial hydrolysis of collagen, the main fibrous protein in animal bones, cartilage and skins.  The use of gelatin plays an important role in pharmaceutical and consumer healthcare industries in applications such as hard and soft gelatin capsule dosage forms.   Particularly the gelatin-based softgel dosage form has fond feedback from consumers in that they ‘have elegance’ and they are ‘easy to ingest’.  So naturally consumer businesses are eager to offer their products in the gelatin dosage form.  As with any dosage form, it is desirable to tune the excipient material to obtain desired performance attributes, such as withstanding harsh climatic environments for the entire shelf life of the product.  In order to design a product with specific function, one needs to know the structure / property / process relations of the material.  Our effort to characterize gelatin materials has involved building our in-house and external capabilities.  The external capabilities involve tools that are unique and not offered commercially or so rare and complex that the tool <i>without</i> the subject matter expert would be moot.  In this presentation we illustrate our effort to develop a sound characterization strategy for gelatin material with an eye toward finding the link between chemistry and product performance.

Understanding gelatin structures through technology collaborations

2019 Spring National Meeting

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