Biological materials provide the inspiration for harnessing design strategies to develop functional bio-nanomaterial interfaces. Biomolecule-materials interactions are simultaneously self-assembled and self-organized; these characteristics are intricate to achieve in purely synthetic systems. Proteins play an essential role with their molecular specificity and efficiency leading to the formation of controlled structures and functions at all scales of dimensional hierarchy. Recognizing this, our group has been exploring peptides as the key fundamental building blocks to mimic biomolecular recognition at the solid material interfaces. Our approach includes decoding the peptide-material interactions and utilizing them in the precision assembly of abiotic/biotic materials. We further engineer these material selective peptide based building blocks to incorporate additional functions as multifunctional chimeric molecules ranging from short peptide chimera to recombinant fusion proteins. Armed with an extensive array of multifunctional molecular units, we design biomimetic interfaces that can guide biomolecular or cellular interactions or offer antimicrobial function.<br/>

Guiding functionality through peptide engineered biomimetic interfaces

2019 Spring National Meeting

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