The baulamycins are a class of structurally-unique, broad-spectrum antibiotic natural products isolated from <i>Streptomyces tempesquensis</i>. Active against a number of clinically-relevant Gram-positive and Gram-negative species, the baulamycins offer the enticing possibility of probing what may be a novel mechanism of bactericidal activity. To date, study has been limited by the extreme scarcity of the baulamycins. A total synthesis has been devised which will provide scalable access to the natural products as well as unnatural derivatives, allowing interrogation of structure-activity relationships within the baulamycin scaffold. The total synthesis of the baulamycin scaffold is described.<br/>

Total synthesis of the baulamycins

2019 Spring National Meeting

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