Tissues are not made up solely of cells. A substantial part of their volume is a network of macromolecules called the extracellular matrix (ECM). It is composed of a variety of proteins (mostly collagen) and polysaccharideswhich serve as a scaffold. This is why collagen is largely used for developing 3D printing structures. In a first study, we have studies the effect of using different collagen formats extracted from the waste of the fishing on the quality of the printed structuredvia gel extrusion 3D-printing. It was concluded that neither formats on their own had ideal properties and that there is a need for an improved cross-linkable bioink for tissue engineering.<br/>In this study, our strategy is to address the issues encountered with collagen printing by using cellulose nanocrystals as a modifier. Collagen and cellulose nanocrystals were characterised and formulated together. Results indicate interesting synergetic effects resulting from the association of collagen and cellulose.

3D-printing of nano-polysaccharide/collagen composite bioink

2019 Spring National Meeting

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