Alzheimer’s disease has a disproportionate impact on African Americans and Hispanics whoc have one and a half to three times higher incidence rates compared to nonHispanic Whites. While socioeconomic, comorbidity, and genetics may partially explain this racial disparity there is a large gap in our understanding of why these disparities exist. Our laboratory thus is using comprehensive proteomics and lipidomics strategies to study if there is a molecular basis underlying these disparities. Specifically, we evaluate blood-based specimens and post-mortem tissues in African American individuals and compare our findings with those from nonHispanic White. High-throughput mass spectrometry techniques are applied to study proteins and lipids, respectively, in the tissues in a small cohort of samples. The ‘omics strategies have been developed in our laboratory as well as implications of our preliminary findings for disease pathogenesis and disparities understanding will be presented.

Comprehensive ‘Omics strategies to study disparities in Alzheimer’s Disease

2019 Spring National Meeting

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