Novel resorbable polymeric materials are needed to address limitations of current synthetic and biologic derived materials for soft-tissue repair. Here we explored a series of L-valine and L-phenylalanine based poly(ester urea)s (PEU)s that possess a variation in monomer diol length, extent of branching, and monomer feed ratio as candidate polymeric materials for soft tissue repair applications. Mechanical properties and in vivo degradation were assessed to determine material properties and inflammatory response. Several processing techniques (compression molding, blade coating, etc.) were employed to develop prototypes for potential hernia-mesh repair applications with the resulting material’s biocompatibility under study. To date, PEUs have shown to be promising alternatives to currently employed synthetic and biologic materials for hernia-mesh repair.

Amino acid-based poly(ester urea)s for soft–tissue repair applications

2019 Spring National Meeting

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