This study demonstrated a process for high-single pass yield (up to 75%) and high-selectivity (~99%) synthesis of glucooligosaccharides (GlOS) from glucose via non-enzymatic glycosylation reaction in acidic lithium bromide trihydrate (ALBTH, a concentrated aqueous solution of LiBr containing a small amount of acid) system. It was revealed through matrix-assisted laser desorption ionization-time of flight mass spectrometry, gel permeation chromatography, and nuclear magnetic resonance analysis that the synthesized GlOS were composed of 2-9 anhydrous glucose units, which were linked predominantly via α/β–1,6 glycosidic bonds (69%), followed by α/β–1,3, α/β–1,2, α/β–1,1, and α–1,4 glycosidic bonds. Preliminary <i>in-vitro</i>fermentation tests with select probiotic strains verified theprebioticpotential of the GlOS. <br/>

Chemical synthesis of glucooligosaccharides directly from glucose as potential prebiotics

2019 Spring National Meeting

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